Wheel camber is applied to the rear wheels of a wheelchair. It can be described as an angling that brings the top of the wheels closer to each other. Athletes who wished to improve wheelchair-handling characteristics and stability first introduced camber into wheelchairs.

The amount of camber introduced into the wheels is measured in degrees. The higher the number the more camber or angling there is. Some wheelchairs have methods of adjusting the camber, while others do not. Camber adjustment is most often accomplished by inserting a different camber bar that alters the angle or by adjusting the axle plate for increased camber. Wheelchairs with fixed camber do not allow for altering the angle. In these cases the camber angle may be specified when the wheelchair is ordered (except in the case of low end cheeseball wheelchairs).

As camber is increased, the width of the wheelchair across the bottom increases. This adds lateral stability to the system by increasing the wheelchairs footprint. If to much camber is added there may be a problem getting through doorways. The amount of camber required for daily use is not commonly the same as that which is required for sports.